Metronidazole
Metronidazole
Definition
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.
Also known as Flagyl, Flagyl I.V. RTU, METRONIDAZOLE, Tricom — per NCIT
Also identified as
- ATC A01AB per NCIT
- ATC A02BD per NCIT
- ATC D06BX per NCIT
- ATC G01AF per NCIT
- ATC J01RA per NCIT
- ATC J01XD per NCIT
- ATC P01AB per NCIT
- NCIT NCIT:C651 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Trichomoniasis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Abscess | may treat | MEDRT · Public domain (U.S. Government work) |
| Amebiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial endocarditis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial vaginosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacteroides infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Clostridium difficile colitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Giardiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Helicobacter pylori infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Rosacea | may treat | MEDRT · Public domain (U.S. Government work) |
| Trichomonas vaginitis urogenital infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Colon | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Female reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Meninx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
13 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.