Flunisolide
Flunisolide
Definition
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Flunisolide is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation.
Also known as FLUNISOLIDE — per NCIT
Also identified as
- ATC R01AD04 per RXNORM
- ATC R03BA03 per RXNORM
- NCIT NCIT:C29054 per NCIT
- SCTID 116588001 per RXNORM
- SCTID 43879000 per RXNORM
- UNII QK4DYS664X per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Asthma | may prevent | MEDRT · Public domain (U.S. Government work) |
| Nasal cavity polyp | may prevent | MEDRT · Public domain (U.S. Government work) |
| Asthma | may treat | MEDRT · Public domain (U.S. Government work) |
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.