Zileuton
Zileuton
Definition
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. (NCI04)
Also known as (+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea, N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea, ZILEUTON, Zyflo — per NCIT
Also identified as
- NCIT NCIT:C26667 per NCIT
- SCTID 108617005 per RXNORM
- SCTID 386180009 per RXNORM
- UNII V1L22WVE2S per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Asthma | may prevent | MEDRT · Public domain (U.S. Government work) |
| Asthma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.