Fluticasone
Fluticasone
Definition
A synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.
Also known as FLUTICASONE — per NCIT
Also identified as
- ATC D07AC17 per RXNORM
- ATC R01AD08 per RXNORM
- ATC R03BA05 per RXNORM
- NCIT NCIT:C61767 per NCIT
- SCTID 108632003 per RXNORM
- SCTID 397192001 per RXNORM
- UNII CUT2W21N7U per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Asthma | may prevent | MEDRT · Public domain (U.S. Government work) |
| Nasal cavity polyp | may prevent | MEDRT · Public domain (U.S. Government work) |
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.