Cladribine
Cladribine
Definition
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
Also known as 2-CdA, 2-Chloro-2-Deoxyadenosine, 2-Chlorodeoxyadenosine, 2CDA, CdA, Cladribina, CLADRIBINE, Leustat, Leustatin, Leustatine, RWJ-26251 — per NCIT
Also identified as
- ATC L01BB04 per RXNORM
- ATC L04AA40 per RXNORM
- NCIT NCIT:C1336 per NCIT
- SCTID 108800000 per RXNORM
- SCTID 386916009 per RXNORM
- UNII 47M74X9YT5 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| B-cell chronic lymphocytic leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Hairy cell leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Multiple sclerosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-Hodgkin lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.