Topotecan
Topotecan
Definition
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
Also known as (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin, Hycamptamine, TOPOTECAN, Topotecan Lactone — per NCIT
Also identified as
- ATC L01CE01 per RXNORM
- NCIT NCIT:C1413 per NCIT
- SCTID 108779005 per RXNORM
- SCTID 372536007 per RXNORM
- UNII 7M7YKX2N15 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Small cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bronchi | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocrine gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.