Entacapone

Definition

A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.

Also known as Comtan, ENTACAPONE — per NCIT

Also identified as

• ATC N04BX02 per RXNORM
• NCIT NCIT:C61746 per NCIT
• SCTID 116116003 per RXNORM
• SCTID 387018000 per RXNORM
• UNII 4975G9NM6T per RXNORM

Indications

Organ Effects

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