Anakinra
Anakinra
Definition
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)
Also known as ANAKINRA, Kinaret, Kineret, rIL-1ra, rIL1RN — per NCIT
Also identified as
- ATC L04AC03 per RXNORM
- NCIT NCIT:C38717 per NCIT
- SCTID 385549000 per RXNORM
- SCTID 395279009 per RXNORM
- UNII 9013DUQ28K per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cryopyrin-associated periodic syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.