Tolcapone

Definition

A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa.

Also known as 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone, Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-, Tasmar, TOLCAPONE — per NCIT

Also identified as

• ATC N04BX01 per RXNORM
• NCIT NCIT:C47762 per NCIT
• SCTID 108464002 per RXNORM
• SCTID 386851002 per RXNORM
• UNII CIF6334OLY per RXNORM

Indications

Organ Effects

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.