Paricalcitol
Paricalcitol
Definition
A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)
Also known as (7e,22e)-19-Nor-9,10-Secoergosta-5,7,22-Triene-1Alpha,3Beta,25-Triol, Compound 49510, PARICALCITOL, Zemplar — per NCIT
Also identified as
- ATC H05BX02 per RXNORM
- NCIT NCIT:C38693 per NCIT
- SCTID 108946001 per RXNORM
- SCTID 126233000 per RXNORM
- UNII 6702D36OG5 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Hyperparathyroidism | may prevent | MEDRT · Public domain (U.S. Government work) |
| Hyperparathyroidism | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Parathyroid glands | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.