Zoledronic Acid

Definition

A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia.

Also known as [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid, Aclasta, CGP 42446, CGP42446A, NDC-Zoledronate, Reclast, ZOL 446, Zoledronate, ZOLEDRONIC ACID, Zometa — per NCIT

Also identified as

• ATC M05BA08 per RXNORM
• NCIT NCIT:C1699 per NCIT
• SCTID 134600006 per RXNORM
• SCTID 395926009 per RXNORM
• UNII 6XC1PAD3KF per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.