Darunavir

Definition

A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication.

Also known as (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate, DARUNAVIR, TMC114 — per NCIT

Also identified as

• ATC J05AE10 per RXNORM
• NCIT NCIT:C65364 per NCIT
• SCTID 423888002 per RXNORM
• SCTID 424096001 per RXNORM
• UNII YO603Y8113 per RXNORM

Indications