Vancomycin
Vancomycin
Definition
A branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
Also known as VANCOMYCIN — per NCIT
Also identified as
- ATC A07AA per NCIT
- ATC J01XA per NCIT
- ATC S01AA per NCIT
- NCIT NCIT:C925 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial endocarditis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bacterial endocarditis | may treat | MEDRT · Public domain (U.S. Government work) |
| Clostridium difficile colitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Diarrheal disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Neutropenia | may treat | MEDRT · Public domain (U.S. Government work) |
| Pneumococcal meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Colon | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Meninx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
9 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.