Hydroxyurea
Hydroxyurea
Definition
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
Also known as Droxia, Hydrea, Hydroxycarbamide, HYDROXYUREA, Litalir, Onco-Carbide, Oncocarbide, Oxeron, SQ 1089, SQ-1089, Syrea, WR 83799 — per NCIT
Also identified as
- ATC L01XX05 per RXNORM
- NCIT NCIT:C560 per NCIT
- SCTID 387314007 per RXNORM
- SCTID 56602009 per RXNORM
- UNII X6Q56QN5QC per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acquired polycythemia vera | may treat | MEDRT · Public domain (U.S. Government work) |
| Brain cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Essential thrombocythemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypereosinophilic syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Melanoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Non-small cell lung carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Ovarian cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Prostate cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Psoriasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Renal cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Squamous cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Uterine cancer | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.