Triamcinolone
Triamcinolone
Definition
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.
Also known as (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Aristocort, TRIAMCINOLONE — per NCIT
Also identified as
- ATC A01AC01 per RXNORM
- ATC C05AA12 per RXNORM
- ATC D07AB09 per RXNORM
- ATC D07XB02 per RXNORM
- ATC H02AB08 per RXNORM
- ATC R01AD11 per RXNORM
- ATC R03BA06 per RXNORM
- ATC S01BA05 per RXNORM
- NCIT NCIT:C901 per NCIT
- SCTID 116594009 per RXNORM
- SCTID 6028009 per RXNORM
- UNII 1ZK20VI6TY per RXNORM
Indications
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adrenal glands | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Thyroid gland | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Uvea | may treat a disease of this organ | DERIVED · CC BY 4.0 |
20 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.