Peginterferon Alfa-2a

ATC Code L03AB11

Peginterferon Alfa-2a

Definition

A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)

Also known as PEG-Interferon Alfa-2a, Pegasys, PEGINTERFERON ALFA-2A, Pegylated Interferon Alfa-2a — per NCIT

Also identified as

Indications

Disease Relation Source
Brain cancer may treat MEDRT · Public domain (U.S. Government work)
Chronic hepatitis B virus infection may treat MEDRT · Public domain (U.S. Government work)
Chronic hepatitis C virus infection may treat MEDRT · Public domain (U.S. Government work)
Colorectal neoplasm may treat MEDRT · Public domain (U.S. Government work)
Common wart may treat MEDRT · Public domain (U.S. Government work)
Cryoglobulinemia may treat MEDRT · Public domain (U.S. Government work)
Essential thrombocythemia may treat MEDRT · Public domain (U.S. Government work)
Hairy cell leukemia may treat MEDRT · Public domain (U.S. Government work)
Hemangioma may treat MEDRT · Public domain (U.S. Government work)
Hepatitis D virus infection may treat MEDRT · Public domain (U.S. Government work)
Hepatocellular carcinoma may treat MEDRT · Public domain (U.S. Government work)
Hypereosinophilic syndrome may treat MEDRT · Public domain (U.S. Government work)
Ileal neoplasm may treat MEDRT · Public domain (U.S. Government work)
Kaposi's sarcoma may treat MEDRT · Public domain (U.S. Government work)
Macular degeneration may treat MEDRT · Public domain (U.S. Government work)
Melanoma may treat MEDRT · Public domain (U.S. Government work)
Multiple myeloma may treat MEDRT · Public domain (U.S. Government work)
Mycosis fungoides may treat MEDRT · Public domain (U.S. Government work)
Renal cell carcinoma may treat MEDRT · Public domain (U.S. Government work)
Sezary syndrome may treat MEDRT · Public domain (U.S. Government work)
Skin neoplasm may treat MEDRT · Public domain (U.S. Government work)
Thrombocytopenia may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Alimentary part of gastrointestinal system may treat a disease of this organ DERIVED · CC BY 4.0
Blood vessel may treat a disease of this organ DERIVED · CC BY 4.0
Bone marrow may treat a disease of this organ DERIVED · CC BY 4.0
Camera-type eye may treat a disease of this organ DERIVED · CC BY 4.0
Liver may treat a disease of this organ DERIVED · CC BY 4.0
Lymphoid system may treat a disease of this organ DERIVED · CC BY 4.0
Retina may treat a disease of this organ DERIVED · CC BY 4.0
Skin of body may treat a disease of this organ DERIVED · CC BY 4.0

8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.